MeBoDD | Geert Carmeliet Lab | Publications

Publications

Selected Publications

COMPLETE BIBLIOGRAPHY

PUBLICATIONS 2024

Loopmans, S., Tournaire, G., Stockmans, I., Stegen, S., Carmeliet, G. (2024) Hypoxia rewires glucose and glutamine metabolism in different sources of skeletal stem and progenitor cells similarly, except for pyruvate. Journal of Bone and Mineral Research, online ahead of print

Stegen, S., Carmeliet, G. (2024) Metabolic regulation of skeletal cell fate and function. Nature Reviews in Endocrinology, online ahead of print

Stegen, S., Moermans, K., Stockmans, I., Thienpont, B., Carmeliet, G. (2024) The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1. Nature Metabolism 6, 141-152

PUBLICATIONS 2023

Carmeliet, G. (2023). Stem cells provide clues to why vertebrae attract tumour cells. Nature 621, 481-482

PUBLICATIONS 2022

Loopmans, S., Stockmans, I., Carmeliet, G., Stegen, S. (2022). Isolation and in vitro characterization of murine young-adult long bone skeletal progenitors. Frontiers in Endocrinology 1, 930358.

Tournaire, G., Loopmans, S., Stegen, S., Rinaldi, G., Eelen, G., Torrekens, S., Moermans, K., Carmeliet, P., Ghesquière, B., Thienpont, B., Fendt, S.-M., van Gastel, N., Carmeliet, G. (2022). Inhibition of oxidative phosphorylation preserves self-renewal in skeletal progenitors. Cell Reports 26, 111105.

Stegen, S., Loopmans, S., Stockmans, I., Moermans, K., Carmeliet, P., Carmeliet, G. (2022). De novo serine synthesis regulates chondrocyte proliferation during endochondral ossification. Bone Research 15, 14.

Devignes, C.-S., Carmeliet, G., Stegen, S. (2022). Amino acid metabolism in skeletal cells. Bone Reports 17:101620.

PUBLICATIONS 2021

van Gastel, N. and Carmeliet, G. (2021). Metabolic regulation of skeletal cell fate and function in physiology and disease.
Nature Metabolism 3, 11-20.

Stegen, S., Devignes, C.-S., Torrekens, S., Van Looveren, R., Carmeliet, P., Carmeliet, G. (2021). Glutamine metabolism in osteoprogenitors is required for bone mass accrual and PTH-induced bone anabolism in male mice. Journal of Bone and Mineral Research 36, 604-616.

Verlinden, L., Carmeliet, G. (2021). Integrated View on the Role of Vitamin D Actions on Bone and Growth Plate Homeostasis. JBMR Plus 5, e10577.

PUBLICATIONS 2020

Stegen, S., Rinaldi, G., Loopmans, S., Stockmans, I., Moermans, K., Thienpont, B., Fendt, S.-M., Carmeliet, P., Carmeliet, G (2020). Glutamine metabolism controls chondrocyte identity and function. Developmental Cell 53, 530-544.

van Gastel, N., Stegen, S., Eelen, G., Schoors, S., Carlier, A., Daniëls, V.W., Baryawno, N., Przybylski, D., Depypere, M., Stiers, P.-J., Lambrechts, D., Van Looveren, R., Torrekens, S., Sharda, A., Agostinis, P., Lambrechts, D., Maes, F., Swinnen, J.V., Geris, L., Van Oosterwyck, H., Thienpont, B., Carmeliet P., Scadden, D.T., Carmeliet, G. (2020). Lipid availability determines fate of skeletal progenitor cells via SOX9. Nature 579, 111-117.

Tournaire G., Stegen S., Giacomini G., Stockmans I., Moermans K., Carmeliet G., van Gastel N. (2020). Nestin-GFP transgene labels skeletal progenitors in the periosteum. Bone. 2020 Feb 6;133:115259.

PUBLICATIONS 2019

Invited review: Stegen S., Carmeliet G. (2019). Hypoxia, hypoxia-inducible transcription factors and oxygen-sensing prolyl hydroxylases in bone development and homeostasis. Curr Opin Nephrol Hypertens. 2019 Jul;28(4):328-335.

Stiers P-J., Stegen S., van Gastel N., Van Looveren R., Torrekens S., Carmeliet G. (2019). Inhibition of the Oxygen Sensor PHD2 Enhances Tissue-Engineered Endochondral Bone Formation. J Bone Miner Res. 2019 Feb;34(2):333-348.

Stegen S.*, Laperre K.*, Eelen G., Rinaldi G., Fraisl P., Torrekens S., Van Looveren R., Loopmans S., Bultynck G., Vinckier S., Meersman F., Maxwell PH., Rai J., Weis M., Eyre DR., Ghesquiere B., Fendt S-M., Carmeliet P., Carmeliet G. (2019). HIF-1 alpha metabolically controls collagen synthesis and modification in chondrocytes. Nature. 2019 Jan;565(7740):511-515.

*shared first co-authorship

PUBLICATIONS 2018

Invited review: Stegen S., Carmeliet G. (2018). The skeletal vascular system - Breathing life into bone tissue. Bone. 2018 Oct;115:50-58.

Stegen S., Stockmans I., Moermans K., Thienpont B., Maxwell PH., Carmeliet P., Carmeliet G. (2018). Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin. Nat Commun. 2018 Jul 2;9(1):2557.

Stiers P-J., van Gastel N., Moermans K., Stockmans I., Carmeliet G. (2018). An Ectopic Imaging Window for Intravital Imaging of Engineered Bone Tissue. JBMR Plus. 2018 Jan 31;2(2):92-102.

PUBLICATIONS 2017

Stiers P-J., van Gastel N., Moermans K., Stockmans I., Carmeliet G. (2017). Regulatory elements driving the expression of skeletal lineage reporters differ during bone development and adulthood. Bone. 2017 Dec; 105:154-162.

PUBLICATIONS 2016

Invited review: Stiers P-J., van Gastel N., Carmeliet G. (2016). Targeting the hypoxic response in bone tissue engineering: A balance between supply and consumption to improve bone regeneration. Mol Cell Endocrinol. 2016 Sep 5;432:96-105.

Stegen S., van Gastel N., Eelen G., Ghesquière B., D'Anna F., Thienpont B., Goveia J., Torrekens S., Van Looveren R., Luyten F., Maxwell PH., Wielockx B., Lambrechts D., Fendt S-M., Carmeliet P., Carmeliet G. (2016). HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival. Cell Metab. 2016 Feb 9;23(2):265-79.

Stegen S., Deprez S., Eelen G., Torrekens S., Van Looveren R., Goveia J., Ghesquiere B., Carmeliet P., Carmeliet G. (2016). Adequate hypoxia inducible factor 1 alpha signaling is indispensable for bone regeneration. Bone. 2016 Jun;87:176-86.

PUBLICATIONS 2015

Lieben L., Verlinden L., Masuyama R., Torrekens S., Moermans K., Schoonjans L., Carmeliet P., Carmeliet G. (2015). Extra-intestinal calcium handling contributes to normal serum calcium levels when intestinal calcium absorption is suboptimal. Bone. 2015 Dec; 81:502-512.

Invited review: Raymaekers K., Stegen S., van Gastel N., Carmeliet G. (2015). The vasculature: a vessel for bone metastasis. Bonekey Rep. 2015 Sep 9;4:742.

Invited review: Carmeliet G., Dermauw V., Bouillon R. (2015). Vitamin D signaling in calcium and bone homeostasis: A delicate balance. Best Pract Res Clin Endocrinol Metab. 2015 Aug;29(4):621-31.

Invited review: Stegen S., van Gastel N., Carmeliet G. (2015). Bringing new life to damaged bone: The importance of angiogenesis in bone repair and regeneration. Bone. 2015 Jan;70:19-27.

Invited review: Roberts SJ.*, van Gastel N.*, Carmeliet G., Luyten FP. (2015). Uncovering the periosteum for skeletal regeneration: The stem cell that lies beneath. Bone. 2015 Jan;70:10-8.

*shared first co-authorship

PUBLICATIONS 2014

van Gastel N., Stegen S., Stockmans I., Moermans K., Schrooten J., Graf D., Luyten F., Carmeliet G. (2014). Expansion of murine periosteal progenitor cells with fibroblast growth factor 2 reveals an intrinsic endochondral ossification program mediated by bone morphogenetic protein 2. Stem Cells. 2014 Sep;32(9):2407-18.

PUBLICATIONS 2013

Lieben L., Stockmans I., Moermans K., Carmeliet G. (2013). Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. Bone. 2013 Nov;57(1):123-31.

Invited review: Lieben L., Carmeliet G. (2013). The delicate balance between vitamin D, calcium and bone homeostasis: Lessons learned from intestinal- and osteocyte-specific VDR null mice. J Steroid Biochem Mol Biol. 2013 Jul;136:102-6.

Invited review: Lieben L., Carmeliet G. (2013). Vitamin D signaling in osteocytes: Effects on bone and mineral homeostasis. Bone. 2013 Jun;54(2):237-43.

Invited review: Bouillon R., Lieben L., Mathieu C., Verstuyf A., Carmeliet G. (2013). Vitamin D action: lessons from VDR and Cyp27b1 null mice. Pediatr Endocrinol Rev. 2013 Jun;10 Suppl 2:354-66.

PUBLICATIONS 2012

van Gastel N., Torrekens S., Roberts SJ., Moermans K., Schrooten J., Carmeliet P., Luttun A., Luyten F., Carmeliet G. (2012). Engineering Vascularized Bone: Osteogenic and Pro-Angiogenic Potential of Murine Periosteal Cells. Stem Cells. 2012 Nov;30(11):2460-71.

Invited review: Lieben L., Carmeliet G. (2012). The involvement of TRP channels in bone homeostasis. Front Endocrinol (Lausanne). 2012 Aug 20;3:99.

Lieben L., Masuyama R., Torrekens S., Van Looveren R., Schrooten J., Baatsen P., Lafage-Proust M-H., Dresselaers T., Feng JQ., Bonewald LF., Meyer MB., Pike WJ., Bouillon R., Carmeliet G. (2012). Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization. J Clin Invest. 2012 May;122(5):1803-15.

Invited review: Maes C., Carmeliet G., Schipani E. (2012). Hypoxia-driven pathways in bone development, regeneration and disease. Nat Rev Rheumatol. 2012 Mar 27;8(6):358-66.

Maes C., Araldi E., Haigh K., Khatri R., Van Looveren R., Giaccia AJ., Haigh JJ., Carmeliet G., Schipani E. (2012). VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival. J Bone Miner Res. 2012 Mar;27(3):596-609.

PUBLICATIONS 2011

Laperre K., Depypere M., van Gastel N., Torrekens S., Moermans K., Bogaerts R., Maes F., Carmeliet G. (2011). Development of micro-CT protocols for in vivo follow-up of mouse bone architecture without major radiation side effects. Bone. 2011 Oct;49(4):613-22.

Invited review: Lieben L., Carmeliet G., Masuyama R. (2011). Calcemic actions of vitamin D: Effects on the intestine, kidney and bone. Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):561-72.

PUBLICATIONS 2010

Vanden Bosch A., Raemaekers T., Denayer S., Torrekens S., Smets N., Moermans K., Dewerchin M., Carmeliet P., Carmeliet G. (2010). NuSAP is essential for chromatin-induced spindle formation during early embryogenesis. J Cell Sci. 2010 Oct 1;123(Pt 19):3244-55.

Maes C., Kobayashi T., Selig MK., Torrekens S., Roth SI., Mackem S., Carmeliet G., Kronenberg HM. (2010). Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. Dev Cell. 2010 Aug 17;19(2):329-44.

Coenegrachts L., Maes C., Torrekens S., Van Looveren R., Mazzone M., Guise T., Bouillon R., Stassen J-M., Carmeliet P., Carmeliet G. (2010). Anti-Placental Growth Factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation. Cancer Res. 2010 Aug 15;70(16):6537-47.

Lieben L., Benn B., Ajibade D D., Stockmans I., Moermans K., Hediger M., Peng J., Christakos S., Bouillon R., Carmeliet G. (2010). Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis. Bone. 2010 Aug;47(2):301-8.

Maes C., Goossens S., Bartunkova S., Drogat B., Coenegrachts L., Stockmans I., Moermans K., Nyabi O., Haigh K., Naessens M., Haenebalcke L., Tuckermann JP., Tjwa M., Carmeliet P., Mandic V., David J-P., Behrens A., Nagy A., Carmeliet G., Haigh JJ. (2010). Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J. 2010 Jan 20;29(2):424-41.

Metabolism in Bone
Development and Disorders

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